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 Fix P0300 misfire code on Silverado Sierra GM has issued a service bulletin #PIP5147A to address a situation where you have a check engine light and retrieve trouble codes relating to a misfire The trouble codes you may find are P0300 P0351 – P0358 P2300, P2301, P2303, P2304, P2306, P2307, P2309, P2310, P2312, P2313, P2315, P2316, P2318, P2319, GM code P0300 indicates that one or more cylinders are experiencing misfires A misfire occurs when an insufficient amount of fuel is burning in a cylinder The efficient burning of fuel is essential to engine operation as the combustion of fuel is what provides the energy to power the engine in your GM I have a P0300 code for a random misfire 02 GMC Sierra 1500 Asked by big01_dram in Pekin, IL on I did a tune up and all was well Shortly after I developed a random misfire New plugs wires, fuel filter It is a coil over system so its not there The only thing I can find is the fuel pressure is low P0300 Code Mechanic Advice To Diagnose And Fix 1a A